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tRF&tiRNA Research Tools

rtStar™ Pre-designed tRF&tiRNA Primer Sets (H/M) — Accurate Quantification of Individual tRFs and tiRNAs

Arraystar supplies pre-designed tRF&tiRNA-specific PCR primers for the accurate quantification of individual tRFs&tiRNAs in qPCR. All the primers have been validated in numerous sample types, and guarantee the most accurate and specific performance when used with Arraystar SYBR® Green qPCR Master Mix.

Fully validated primers · high sensitivity and specificity · 200 reactions per pair

Overview

Validated qPCR primer pairs for individual tRF&tiRNA quantification

rtStar™ Pre-designed Human tRF&tiRNA Primer Sets are part of the nrStar™ tRF&tiRNA PCR System, and can be used in combination with the rtStar™ First-Strand cDNA Synthesis Kit (3′ and 5′ adaptor) (AS-FS-003) for tRF&tiRNA detection and quantification.

All the primers have been validated in numerous sample types, and guarantee the most accurate and specific performance when used with Arraystar SYBR® Green qPCR Master Mix. Human and Mouse primer lists provide tRF&tiRNA names, sequences, source tRNAs, and catalog numbers.

What are pre-designed tRF&tiRNA primer sets?

Pre-designed tRF&tiRNA primer sets are validated qPCR primer pairs targeting individual tRFs and tiRNAs. Used with the rtStar™ First-Strand cDNA Synthesis Kit (3′ and 5′ adaptor) and Arraystar SYBR® Green qPCR Master Mix, they enable accurate, specific quantification of individual tRFs&tiRNAs.

Service at a Glance

Standard catalog products — human and mouse versions available

Product NameCatalog No.SizePrice
rtStar™ Pre-designed Human tRF&tiRNA qPCR Primer PairAS-NR-002-1-M200 reactions
rtStar™ Pre-designed Mouse tRF qPCR Primer PairAS-NR-002M-1-M200 reactions

Benefits

Why researchers choose rtStar™ Pre-designed tRF&tiRNA Primer Sets

Reliable Results

Reliable results with fully validated primers.

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High Sensitivity & Specificity

High sensitivity and specificity for individual tRF&tiRNA quantification.

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Wide Linear Range

Accurate quantification over a wide linear range.

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Time & Cost Savings

Time and cost savings with validated primers and SYBR® Green assay.

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Validated in Many Sample Types

All primers validated in numerous sample types.

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System-Compatible

Performs superbly with the rtStar™ First-Strand cDNA Synthesis Kit (3′ and 5′ adaptor) (CAT# AS-FS-003) and Arraystar SYBR® Green qPCR Master Mix.

Background

Primer validation and performance

The rtStar™ Pre-designed Human tRF&tiRNA Primer Sets are part of the nrStar™ tRF&tiRNA PCR System, and can be used in combination with the rtStar™ First-Strand cDNA Synthesis Kit (3′ and 5′ adaptor) (AS-FS-003) for tRF&tiRNA detection and quantification.

All the primers have been validated in numerous sample types, and guarantee the most accurate and specific performance when used with Arraystar SYBR® Green qPCR Master Mix. Each primer pair produces a single specific amplification product, as demonstrated by amplification and dissociation curves (Fig. 1).

Figure 1. Amplification curve (A) and Dissociation curve (B) of example Human tRF-5005A.
Figure 1. Amplification curve (A) and Dissociation curve (B) of example Human tRF-5005A.

Primer Set Workflow

From RNA to individual tRF&tiRNA quantification

1

RNA Preparation

Purified total RNA (with small RNAs retained) is quality checked.

2

cDNA Synthesis

The rtStar™ First-Strand cDNA Synthesis Kit (3′ and 5′ adaptor) (AS-FS-003) ligates adaptors and synthesizes cDNA from pretreated tRF&tiRNA fragments.

3

qPCR Setup

Pre-designed primer pairs are combined with cDNA and Arraystar SYBR® Green qPCR Master Mix.

4

Real-Time PCR

qPCR is run on a standard real-time PCR instrument.

5

Quantification

Individual tRF&tiRNA levels are quantified from the amplification and dissociation curves.

Bioinformatics & Deliverables

Product specifications, primer lists, and manuals

Human and Mouse primer lists provide full annotation of each assay: tRF&tiRNA name, tRF sequence, source tRNA, and catalog number. Each primer pair is sold with 200 reactions.

Standard Deliverables

Research Applications

Individual tRF&tiRNA quantification applications

Individual tRF/tiRNA Quantification

Accurate detection and quantification of specific tRFs and tiRNAs of interest by qPCR.

Biomarker Validation

Validate tRF/tiRNA biomarker candidates identified by sequencing in larger sample cohorts.

Biofluid Studies

Primers validated in numerous sample types support quantification in biofluids.

Disease Research

Quantify specific tRFs/tiRNAs in cancer, cardiovascular, and metabolic disease studies.

Sample Requirements

Recommended RNA input for pre-designed tRF&tiRNA primer set projects

RNA Amount & Quality

  • Total RNA input: > 5 µg per sample is recommended for tRF&tiRNA qPCR projects (official Arraystar recommended minimum for the entire experiment in a single attempt, including sample QC).
  • Purification: TRIzol / RNA precipitation or an RNA isolation kit. Because tRF&tiRNA are < 200 nt, use a kit specified to retain small RNAs (e.g. Qiagen miRNeasy).
  • Concentration: > 20 ng/µL by Nanodrop; OD260/280 ~2.0 (acceptable 1.7–2.1); OD260/230 > 1.8.
  • Integrity: sharp 18S/28S rRNA bands by gel, or RIN > 7.0 by Bioanalyzer (serum/plasma/exosome/FFPE RNA exempt).
  • DNase treatment: required because the sample is used for qPCR.

Shipping Instructions

  • Ship RNA in nuclease-free water (> 20 ng/µL), freeze-dried, or in ethanol; store at −80 °C or in liquid nitrogen.
  • Use nuclease-free certified, screw-cap 1.5 mL microtubes; seal caps with Parafilm; place tubes in a plastic bag.
  • Use 10 kg dry ice as refrigerant; include a signed Project Form and the sample list.
  • Ship to: Arraystar Inc., 9430 Key West Avenue #128, Rockville, MD 20850, USA. Contact us before shipping.

FAQ

Common questions about rtStar™ Pre-designed tRF&tiRNA Primer Sets

What do the pre-designed tRF&tiRNA primer sets include?
Each set includes validated qPCR primer pairs for individual tRFs and tiRNAs. Human and Mouse primer lists provide the tRF&tiRNA name, tRF sequence, source tRNA, and catalog number for each assay, and each primer pair is supplied for 200 reactions.
Which kit must be used with the primer sets?
The primer sets are used in combination with the rtStar™ First-Strand cDNA Synthesis Kit (3′ and 5′ adaptor) (AS-FS-003) for tRF&tiRNA detection and quantification, together with Arraystar SYBR® Green qPCR Master Mix for the most accurate and specific performance in real-time PCR.
How were the primers validated?
All primers have been validated in numerous sample types and guarantee the most accurate and specific performance when used with Arraystar SYBR® Green qPCR Master Mix. Validation includes amplification curves and dissociation curves, for example the Human tRF-5005A assay shown on this page.
What is the recommended RNA input?
We recommend more than 5 µg of total RNA per sample for tRF&tiRNA qPCR projects — the official Arraystar recommended minimum for the entire experiment in a single attempt, including sample QC. Supplying twice the recommended minimum helps avoid project delays. DNase treatment is required for qPCR.
How many reactions does each primer pair provide?
Each rtStar™ Pre-designed Human tRF&tiRNA or Mouse tRF qPCR Primer Pair is supplied for 200 reactions (Catalog Nos. AS-NR-002-1-M and AS-NR-002M-1-M), with the product manual describing recommended assay conditions and SYBR® Green protocols for reliable quantification of each individual tRF.
Can I order primers for specific tRFs of interest?
Yes. The published Human and Mouse primer lists cover prevalent tRFs and tiRNAs with catalog numbers, so you can order individual primer pairs for the specific tRFs/tiRNAs in your study. Contact us if your target is not listed, and our team can advise on availability.

Selected Publications

Featured Client Publications in tRF&tiRNA Research

  1. Tao EW, et al. A specific tRNA half, 5′tiRNA-His-GTG, responds to hypoxia via the HIF1a/ANG axis and promotes colorectal cancer progression by regulating LATS2. Journal of Experimental & Clinical Cancer Research, 2021. PMID: 33588913
  2. Kuang M, et al. tRNA-based prognostic score in predicting survival outcomes of lung adenocarcinomas. International Journal of Cancer, 2019. PMID: 30838640
  3. Deng Z, et al. tRNA-Derived Fragment tRF-5009A Regulates Autophagy and Degeneration of Cartilage in Osteoarthritis via Targeting mTOR. Oxidative Medicine and Cellular Longevity, 2022. PMID: 36035226
  4. Ma C, et al. tRNA-derived fragment tRF-1020 ameliorates diabetes-induced retinal microvascular complications. Journal of Cellular and Molecular Medicine, 2022. PMID: 36128646

Ready to Quantify Individual tRFs and tiRNAs?

rtStar™ Pre-designed tRF&tiRNA Primer Sets deliver validated, specific qPCR quantification — request a quote or ask about the primer list for your tRF/tiRNA of interest.