Arraystar is a research-driven company focused on transfer RNA (tRNA) biology and epitranscriptomics. Since 2009 we have built an integrated portfolio of sequencing, microarray, PCR array, and mass-spectrometry technologies that help scientists decode tRNA expression, tRNA modification, and tRNA charging, together with tRF and tiRNA research. Our tools and services have supported more than a thousand peer-reviewed publications and thousands of research institutions worldwide.
A tRNA-focused company with a track record in ncRNA and epitranscriptomics
Transfer RNAs were long viewed as passive adaptors that simply deliver amino acids to the ribosome. A wave of recent discoveries has overturned this picture: tRNAs are dynamically regulated molecules whose expression, modification, and charging states shape translation efficiency, protein folding, and cellular stress responses. tRNA isoacceptors and isodecoders carry distinct regulatory functions, and tRNA-derived fragments (tRFs) and halves (tiRNAs) act as functional small non-coding RNAs in cancer, neurodegeneration, and metabolism.
tRNAs also carry the most chemically diverse set of post-transcriptional modifications of any RNA class, including m1A, m3C, m1G, m2,2G, m7G, and acp3U. These marks control codon reading, tRNA stability, and translation fidelity, and their dysregulation is increasingly linked to human disease. Profiling them accurately requires dedicated chemistry and bioinformatics, which is exactly what Arraystar has specialized in for more than a decade.
Our tRNA portfolio spans the three key determinants of tRNA function: tRNA Sequencing for expression, tRNA Charging Seq for simultaneous expression, modification, and charging, TRAC-Seq and HAC-Seq for single-nucleotide m7G and m3C detection, LC-MS for full-spectrum modification quantification, and PCR arrays plus pretreatment kits for high-throughput validation. Every workflow is paired with publication-ready bioinformatics.
Our vision is a complete, integrated view of tRNA biology: expression, modification, and charging profiled in the same experimental framework, then connected to translation, stress response, and disease. We aim to make tRNA and tRF/tiRNA analysis as accessible and reliable as mRNA analysis, with technologies that keep pace with the fastest-moving questions in the field.
Arraystar is committed to helping researchers decode the biology of tRNA and tRNA-derived molecules. We provide best-in-class sequencing, array, and mass-spectrometry solutions, rigorous sample-to-data workflows, and expert scientific support, so that labs of every size can turn tRNA questions into translational discoveries.
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Sequencing, modification profiling, and PCR arrays for tRNA, tRF and tiRNA research.
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