Reviews

ArticleMitochondrial translational defect extends lifespan in C. elegans by activating UPRmt Published inRedox Biology AbstractThis study investigated the role of mitochondrial threonyl-tRNA synthetase (TARS-1) in regulating mitochondrial translation and organismal aging in Caenorhabditis elegans. The authors discovered that a single tars-1 gene generates both cytoplasmic and mitochondrial threonyl-tRNA synthetases through translational reinitiation. Deficiency of mitochondrial

ArticleHigh-fat diet driven post-operative colon cancer recurrence is dependent upon genetic susceptibility to deoxycholic acid Published inCancer Lett AbstractThis study investigated how a high-fat diet contributes to postoperative colorectal cancer recurrence and explored the underlying role of transfer RNA (tRNA) regulation. Using a murine model of postoperative tumor formation, the authors demonstrated that the tumor-promoting

Article Cross-talks between Metabolic and Translational Controls during Beige Adipocyte Differentiation Published in Nature Communications Abstract This study uncovered previously unrecognized interactions between cellular metabolism and translational regulation during beige adipocyte differentiation. By integrating transcriptomic, translatomic, and proteomic analyses, the authors identified selective translational remodeling that shapes thermogenic adipocyte metabolism. A key finding was that

ArticleAging-induced tRNA(Glu)-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization Published inCell Metabolism AbstractThis study identified a novel role for a tRNA-derived fragment generated from tRNA(Glu) during aging. The aging-associated tRNA(Glu)-derived fragment (tRF-Glu) accumulated in multiple tissues and disrupted mitochondrial function by impairing mitochondrial translation and cristae organization. Increased tRF-Glu levels reduced glutamate