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mRNA/lncRNA Organized R-loops: An Active Player in Transcription Regulation

Introduction R-loops are three-stranded RNA:DNA loops  when the nascently transcribed RNA anneals with the template DNA strand and displaces the non-template DNA as unpaired single strand. Besides nascent mRNAs, long non-coding RNAs (lncRNAs) may also create and form R-loops.  Mounting evidences now support cells can harness R-loops to regulate gene expression in ways including epigenetic regulation, […]

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How to Choose the Appropriate Tool for Small RNA Modification Research?

Arraystar offers both tRNA Modification Seq-m1A/m3C/m1G/m2,2G and Small RNA Modification Microarray for small RNA modification profiling. The comparison chart below can help you choose the most appropriate tool for your research purpose. tRNA Modification Seq-m1A/m3C/m1G/m2,2G Small RNA Modification Microarray For tRNA only For multiple small RNA classes including miRNAs, pre-miRNAs, tRNAs and tsRNAs(tRFs and tiRNAs). Single-base resolution of modification sites, important info for

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The Challenges and Solutions of Studying Modified Small RNAs

How to Choose the Appropriate Tool for Small RNA Modification Research? Molecular Mechanisms of Small RNA Modifications Small RNA Modifications: Integral to Functions and Diseases The Challenges and Solutions of Studying Modified Small RNAs Profiling small RNA modifications is a key step in studying the increasingly important epitranscriptomics of the small RNA classes. However, not

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Small RNA Modifications: Integral to Functions and Diseases

How to Choose the Appropriate Tool for Small RNA Modification Research? Molecular Mechanisms of Small RNA Modifications Small RNA Modifications: Integral to Functions and Diseases The Challenges and Solutions of Studying Modified Small RNAs Introduction Small RNAs, including microRNAs (miRNAs) and tRNA-derived small RNAs (tsRNAs), harbor a diversity of RNA modifications. RNA modifications such as

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Limitations of m6A-seq and Solutions of Arraystar m6A Single Nucleotide Arrays

N6-methyladenosine is the most abundant RNA modification in mammalian mRNA and long non-coding RNA, occurring on average in three to five sites per transcript[1,2]. Profiling m6A at single nucleotide resolution has been challenging. m6A on lower abundance mRNAs/lncRNAs, the inert reactivity of the methyl group, and interference from RNA structure near the modification site further contribute

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m1A, m5C, ac4C, m7G, and pseudouridine epitranscriptomic modifications in mRNA and lncRNA

In addition to m6A as the most studied prominent internal epitranscriptomic modification in mRNA and long non-coding RNAs (lncRNAs), other epitranscriptomic modifications, such as m1A, m5C, ac4C, m7G, and Ψ, have been increasingly discovered to play novel biological or clinical roles. Arraystar now provides Epitranscriptomic microarray and Epitranscriptomic sequencing services to profile these modifications transcriptome-wide.

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Why Is m6A Modification in Circular RNA Important?

CircRNAs are an unusual RNA class exerting their biological functions by regulating gene transcription and splicing [1, 2], encoding small peptides [3, 4], and acting as sponges for miRNAs through their miRNA binding sites [5, 6]. Like in mRNAs, m6A is the most abundant internal epitranscriptomic modification in circRNAs [7].  m6A modification in circRNAs is installed by writers, e.g.

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