tRNAs are abundant small RNAs essential for delivering amino acids and decoding genetic codons during protein translation. Beyond this canonical role, tRNAs actively regulate translation and disease processes through changes in tRNA expression, modification, and charging, three key determinants of tRNA function. Altered tRNA expression can reshape codon-dependent translation, while tRNA modifications (e.g., m7G, m1A) influence translational speed and fidelity. tRNA charging directly controls translation efficiency, as only charged tRNAs participate in protein synthesis; reduced charging can impair translation and contribute to cellular dysfunction. Increasing evidence links abnormalities in these tRNA features to cancer, cardiovascular, neurodegenerative, and infectious diseases.
Arraystar provides comprehensive sequencing, microarray, PCR, and LC–MS services to support tRNA charging, expression, and modification studies, empowering advanced research into tRNA function and disease mechanisms.
tRNA Charging
tRNA Expression
tRNA Modification
tRNA Modification Seq – m1A, m3C, m1G, m2,2G
LC-MS Based tRNA Modification Analysis
tRNA Related Reagents and Kits
rtStar™ tRNA Pretreatment & First-Strand cDNA Synthesis Kit