Reviews

Unlike well established protein coding genes, publically available long non-coding RNAs (lncRNAs) are often sparsely annotated, partial in scope and scattered in collection. For example, large proportions of reported “lncRNAs” are assembled from short sequencing reads and tend to be incomplete at 5’ or 3’ends. Very often, cDNA libraries are truncated at 5’-ends due to […]

The Arraystar LncRNA microarray package includes systematic and detailed long non-coding RNA (lncRNA) annotations, subclassification, and analyses to gain insight into the complex biological functions of the lncRNAs. LncRNAs with reported biological processes or associated with human diseases are researched, annotated and cross referenced. This rich source of information helps to unravel functional roles and

nrStar™ Functional LncRNA PCR Arrays have an outstanding long non-coding RNA (lncRNA) content selection leading the field of LncRNA research. The LncRNAs that have been associated with diseases including cancers, cardiovascular diseases and neurodegenerative diseases are carefully categorized and annotated in detail to facilitate the researchers’ study and biomarker validation. Best coverage  Well-known LncRNAs characterized for

Overview Long non-coding RNAs (LncRNAs) are a class of non-protein coding RNAs longer than 200 nt. LncRNAs can regulate gene expression by various mechanisms with biological functions in, for example, embryonic development [1], stem cell pluripotency, cell lineage specification, genomic imprinting, cardiac development [2], hematopoiesis, immunity [3], and endocrine systems [4]. Dysregulated expression of lncRNAs

Long non-coding RNAs (LncRNAs) and mRNAs share certain common properties that allow them to be profiled together. However, lncRNAs also have characteristics significantly different from mRNAs, which pose special challenges for their expression profiling, particularly in the choice of profiling technologies. Arraystar lncRNA Arrays are specially designed to meet these challengers, offering irreplaceable benefits over

Unlike protein coding genes, publically available long non-coding RNAs (lncRNAs) are often scantily annotated, partial in scope and scattered in collection. Arraystar maintains high quality proprietary transcriptome and lncRNA databases to extensively collect lncRNAs through our lncRNA discovery pipelines, external data sources, and knowledge-based mining of scientific publications. Arraystar Human LncRNA Array V4.0 has a total of

Microarrays have been used for decades as the standard technology platform for gene expression profiling.  In recent years, Next Generation Sequencing (NGS), which measures gene expression levels by quantifying transcript read densities in the whole transcriptome, has become increasingly popular for gene expression studies. Long non-coding RNAs (LncRNAs) are non-protein coding transcripts longer than 200

LncPath™ Pathway Focused LncRNA Arrays Long non-coding RNAs (LncRNAs) are non-coding RNA transcripts longer than 200 nt. LncRNAs play important roles in a wide range of biological processes. Dysregulated LncRNAs are associated with many complex human diseases such as cancers, Alzheimer’s disease, and heart diseases. To facilitate the functional study of LncRNAs and the understanding

Introduction In higher eukaryotes, multi-exon genes can encode different transcript isoforms via alternative splicing (AS), greatly increasing the diversity of proteins. A vast variety of isoforms generated by alternative splicing have specific roles in tissues or stages of development., Further, changes in normal isoform expression have phenotypic consequences and have been associated with disease [1]. For example,

LncRNAs are RNA transcripts that resemble protein-coding messenger RNAs (mRNAs) in practically every way except that they do not encode proteins. LncRNAs have recently emerged as major players in governing fundamental biological processes. Profiling expression levels of LncRNAs poses a number of special challenges, including: •  Lack of comprehensive and reliable public LncRNA databases •  Low expression