Reviews

What are super enhancer lncRNAs? Super-enhancer lncRNA (SE-lncRNAs), emerging as a novel class of master RNA regulators, is a special set of long noncoding RNAs transcribed from super-enhancer genomic loci. SE-lncRNAs, together with super-enhancers, activate the nearby gene expression by mechanisms of transcription factor trapping, chromatin looping, chromatin modification, PolII loading, and release of transcriptional repressor (Fig. 1). Also, SE-lncRNAs are increasingly

Arraystar Super-Enhancer LncRNA Arrays are the first commercially available solution for sensitive and accurate SE-lncRNA profiling. The SE-lncRNAs are compiled on the foundation of Arraystar Gold standard & Reliable long non-coding RNA (lncRNA) collections and authoritative super-enhancer databases. “Super lncRNAs”, a special class of SE-lncRNA, are also included in the array contents. To experimentally observe,

Super-enhancer lncRNAs have been demonstrated master regulatory functions in biology and diseases, such as myogenesis, cardiomyocyte differentiation, erythropoiesis, fibrosis in post-myocardial infarction, and cancers. The innovative Arraystar Super-enhancer LncRNA Arrays simultaneously profile the super-enhancer lncRNAs and their target genes. The detailed annotation, analysis and cross-references are provided to facilitate the in-depth study on SE-lncRNAs and

Introduction In higher eukaryotic cells, multi-exon genes can produce transcript isoforms by alternative splicing, greatly increase the variations of the encoded proteins. Many alternatively spliced transcript isoforms play distinct roles in different tissues and developmental stages. The aberrant expression of these transcript isoforms can lead to phenotypical changes and associate with diseases [1]. Similarly, super-enhancer

Super-enhancer lncRNAs are generally labile and short in half-lives. They can function at low copy numbers per cell to activate the target genes by cis-mechanism. For example, LncRNA-HOTTIP can activate the HOXA gene cluster with an average of less than one copy per cell. To accurately detect and quantify the transient, low level SE-lncRNAs, Arraystar