Article

Restoration of N-glycosylation via leucine-activated leucyl-tRNA synthetase 1 overcomes chemoresistance in intrahepatic cholangiocarcinoma

Published in

Journal of Hepatology

Abstract

The study demonstrates that leucyl-tRNA charging by LARS1 plays a central role in controlling selective translation and N-glycosylation pathways that determine chemotherapy sensitivity in intrahepatic cholangiocarcinoma. Reduced LARS1 activity promotes chemoresistance through translational defects that impair glycosylation of key transport proteins. These findings highlight tRNA charging as an important regulatory layer in cancer biology and suggest that leucine supplementation may represent a novel strategy to overcome chemotherapy resistance.

Fig 1. LARS1-dependent tRNA charging regulates N-glycosylation and chemotherapy response.

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