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Nature Communications 丨 tRNA Cleavage Defends Against Viral Infection


Fig. 1. Phage D15 nuclease activates retron to cleave host cell tRNA-Tyr, aborting the phage infection [1].


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Retron complexes are a bacterial defense system against phage infection. Published in Nature Communications [1], the retron defense mechanism has now been elucidated, where infecting phage D15 nuclease triggers retron complex dissociation and activates retron nuclease to cleave the host tRNA-Tyr, thereby protecting the host cells against invading phages. Arraystar tRF&tiRNA-seq was used to analyze the specific cleavage of host tRNA-Tyr.

   

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•  tRF&tiRNA focused annotation, bioinformatics and statistics analyses.

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• For human, mouse, and rat species only


References

[1] Ishikawa J. et al (2025) "Structural mechanism of the Retron-Eco7 anti-phage defense system." Nat Commun 16(1):10821 [PMID:41330933]



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