Beyond their classical role in protein synthesis, tRNAs are emerging as powerful regulators of translation and disease processes through dynamic changes in tRNA expression, modification, and charging.

Arraystar mim-tRNA-seq service, by overcoming technical barriers caused by strong tRNA structures and extensive modifications, enables accurate and quantitative simultaneous profiling of tRNA charging, expression, and modification, providing a comprehensive view of tRNA regulatory functions in protein translation and disease research.

• Simultaneous tRNA profiles: tRNA expression, tRNA modification, and tRNA charging.
• High yields for full length tRNAs: Highly efficient full length cDNA synthesis by TGIRT to reduce mapping/counting inaccuracy.
• Broad modification coverage: tRNA modifications, e.g. m1A, m1G, m3C, acp3U, are predicted at single nucleotide resolution.
• Seamless integration with translatomics: To correlate tRNA charging with translation activities.
• Rich data and analyses: A wealth of tRNA multi-omics data come with common analyses (e.g. differential analyses) and detailed annotations (Fig. 1), for comprehensive insights into the tRNAs.

Fig 1. Differential tRNA Charging Analysis

Turnkey Solutions for tRNA Research

From tRNA Expression, Modification, Charging to Disease Mechanisms

Arraystar provides comprehensive sequencing, microarray, PCR, and LC–MS services to support tRNA charging, expression, and modification studies, empowering advanced research into tRNA function and disease mechanisms.

More New tRNA Technologies Are Coming Soon! Subscribe to Our Newsletters to Stay Updated.

• Epitranscriptomic Array
   [PMID: 41717060] Hualong Zhu,et al.
   (2026) Eco-Environment & Health

• tRF&tiRNA Pretreatment Kit
   [PMID: 41555020] Xu M, et al.
  (2026) Nature Biotechnology

• tRF&tiRNA Sequencing
   [PMID: 41330933]
    FJunichiro Ishikawa, et al.
   (2026) Nat Communications

• LncRNA Array
  [PMID: 41519884] Hyeon-Ji Kim,
  et al (2026) Signal Transduction and
  Targeted Therapy

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tRNA Modification Seq Service
Profile m1A, m3C, m1G, m2,2G in tRNAs
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