Fig. 1. lncRNA Wee1-AS controls mitochondrial function through the activation of CDK1/CYCLIN B1 [1].

Customer Success Story

A novel lncRNA Wee1-AS was identified as a critical hepato-protective factor transcriptionally induced by high-fat diet challenge [1]. Overexpression of Wee1-AS potently ameliorates pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), establishing its function as a metabolic switch that enhances mitochondrial fatty acid oxidation. The discovery of lncRNA Wee1-AS represents a fundamental breakthrough in understanding the molecular basis of MASLD, establishing the first direct link between lncRNA-mediated cell cycle regulation and hepatic metabolism. The immediate clinical potential through adavosertib repurposing is particularly remarkable, offering an accelerated development pathway for a disease affecting 30% of adults worldwide with limited therapeutic options.

Arraystar LncRNA Arrays

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References

[1] Kim HJ. et al (2026) "LncRNA Wee1-AS coordinates oxidative fatty acid metabolism through the activation of mitochondrial CDK1/CYCLIN B1." Signal Transduct Target Ther 11(1):13 [PMID:41519884]

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   (2025) ACS Nano

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