|
Customer Success Story
Radioresistance represents a substantial challenge in cancer treatment. Using Arraystar snoRNA PCR Array, snoRNA SNORA58 was found up-regulated in esophageal squamous cell carcinoma (ESCC). SNORA58 enhances cancer cell resistance to radiotherapy by inhibiting ubiquitin-mediated degradation of CTCF, leading to downregulation and inactivation of JNK signaling pathway, disrupted intracellular iron homeostasis, and radiotherapy-induced ferroptosis. These findings are the first to demonstrate SNORA58 as a critical regulator of cancer radioresistance, suggesting potential therapeutic strategies for ESCC.
References
[1] Zheng Y. et al (2025) "SNORA58 Facilitates Radioresistance via Suppressing JNK1-Mediated Ferroptosis in Esophageal Squamous Cell Carcinoma." Adv Sci (Weinh) :e08515 [PMID:40714828]
|
|
Arraystar nrStar™ snoRNA PCR Arrays (30% OFF)
• Excellent coverages - For all the PCR-distinguishable snoRNAs, snoRNA targets, and snoRNP members in one Panel.
• Unmatched sensitivity - As little as 50 ng total RNA. No pre-amplification necessary.
• Proven performance - All snoRNAs have been fully experimentally validated with cell/tissue/serum/plasma samples.
• Fast and easy, ready-to-use format.
• Biomarker discovery - The coverage, sensitivity, accuracy, and throughput are excellent for biomarker screening and validation work.
Related Service: Arraystar snoRNA Sequencing Service
|
