R-loops are RNA:DNA three-stranded hybrid structures formed between LncRNA/mRNA and the template DNA strand by base pairing. R-loops have important biological functions in DNA replication, epigenetic and transcription regulation.

Epigenetic regulation by R-loops

• DNA methylation regulation

• Chromatin remodeling

• lncRNA anchor

Transcription regulation by R-loops

• As gene promoter

• As regulator of transcription factor/repressor binding

• In transcription regulation stabilization

R-loops in human diseases

• Cancers

• Neurological disorders

• Autoimmune diseases

Learn more>>.

Fig. 1. R-loops in human diseases

Arraystar DRIPc-seq profiles LncRNA/mRNA organized R-loops in the genome. The DRIPc-seq, along with LncRNA Array, MeDIP-seq, or ChIP-seq, provides valuable functional insights in epigenetic and transcriptional regulation by R-loops.

Notes:
1. Offer valid through 04/30/2026. May not be combined with any other promotions or discounts.
2. Offer only valid for direct purchase from Arraystar Inc.
3. Minimum 6 samples (i.e. 3 samples in each condition/group) for R-loop differential analysis.

• tRNA Pretreatment Kit
  [PMID: 40461825] Tao E, et al.
   (2025) Nature Cancer

• Epitranscriptomic Array
   [PMID: 41103024] Fu J, et al.
   (2025) Cancer Commun

• Circular RNA Array
   [PMID: 40955561] Carolina G, et al.
   (2025) Circulation Research

• LncRNA Array
   [PMID: 40338223] Gao M, et al.
   (2025) ACS Nano

rG4 Array Service

Uncover RNA G-quadruplexes functions
in biology and disease

Request Quote

DoG RNA Array Service
Profile downstream-of-gene transcripts & all their target types simultaneously

Request Quote

tRNA Modification Seq Service
Profile m1A, m3C, m1G, m2,2G in tRNAs
at single-base resolution

Request Quote

30% OFF PCR Arrays & qPCR Master Mix!

ncRNA PCR Arrays(tRNA, snoRNA & more)

mRNA PCR Arrays(Central Metabolism & more)

Save now>>

Valid through 3/31/2026

30% OFF Small RNA NGS Solutions

tRNA-seq | tRNA Modification-seq

microRNA-seq | piRNA-seq

snoRNA-seq | tRF&tiRNA-seq

Save now>>

Valid through 1/31/2026