Fig. 1. Graphic abstract [1].

Customer Success Story

Circular RNA circ-Cdr1as was identified on Arraystar CircRNA Microarray as one of the most downregulated in pro-inflammatory macrophages and significantly upregulated in anti-inflammatory macrophages [1]. Overexpression of circ-cdr1as in macrophages injected into the ischemic myocardium retains the anti-inflammatory phenotype and significantly improves left ventricular functions and reduced infarct size [2]. Systemic delivery of AAV9-circ-cdr1as has cardiac reparative activity. circ-cdr1as binds miR-7 as identified by Arraystar circRNA-miRNA target prediction, which regulates KLF4 mRNA in heart inflammation postcardiac injury (Fig.1).

Arraystar Circular RNA Arrays

• The only practical platform for highly sensitive and specific circular RNA profiling. Learn more>>

• Circular junction-specific probes, linear RNA removal and efficient circRNA labeling ensure the most specific, accurate, and reliable circRNA expression profiling.

• Detailed annotation specific to circRNA biology, e.g. miRNA binding sites, miRSVR scores and conservation status, to unravel functional roles as miRNA sponges.

• Fast and easy, ready-to-use format.

• The preferred choice over RNA-sequencing, due to the particular properties of circular RNA. Learn more>>

Reference

[1] Gonzalez C. et al (2025) "Circular RNA Cdr1as Modulates Macrophage-Mediated Cardiac Reparative Function." Circ Res 137(9):1207-1221 [PMID:40955561]
[2] Gonzalez C. et al (2022) "Role of circular RNA cdr1as in modulation of macrophage phenotype." Life Sci 309:121003 [PMID:36181865]

• Epitranscriptomic Array
   [PMID: 38355624] Xiong YW, et al.
   (2024) Nature Communications

• Small RNA Modification Array
   [PMID: 38747146] Zhang J, et al.
   (2024) Circulation Research

• Circular RNA Array
   [PMID: 39695693] Hu Y, et al.
   (2024) Molecular Cancer

• tRNA Sequencing
   [PMID: 38519786] Wu X, et al.
   (2024) Nature Cancer

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