Fig. 1. m5C-modified circRREB1 promotes lung cancer progression by inducing mitophagy [1].

Customer Success Story

Using Arraystar CircRNA Epitranscriptomic Array, circular RNA circRREB1 was found differentially modified with m5C by methyltransferase NSUN2 in lung cancer cells [1]. The modification facilitates its nuclear export via m5C reader ALYREF to induce mitophagy through HSPA8/PINK1/Parkin signaling axis, ultimately promoting lung cancer development. These findings also provide potential targets for lung cancer therapy.

Reference
[1] Cai D. et al (2025) "m5C-modified circRREB1 promotes lung cancer progression by inducing mitophagy." J Exp Clin Cancer Res 44(1):203 [PMID:40653497]

Arraystar Epitranscriptomic Arrays

Quantify your choice of m6A/m5C/m1A/ac4C/m7G/Ψ epitranscriptomic modification in mRNAs & lncRNAs or circRNAs.

• A single Epitranscriptomic Microarray to simultaneously profile what gene transcripts are modified, differential modification between conditions, and very importantly, the percentage of modification for each transcript.

• Excellent coverage for coding and noncoding RNA classes, even for lncRNAs and circRNAs that are difficult to profile by MeRIP-seq.

• Faster, simpler than MeRIP-seq.

• Low sample amount required.

• Epitranscriptomic Array
   [PMID: 38355624] Xiong YW, et al.
   (2024) Nature Communications

• Small RNA Modification Array
   [PMID: 38747146] Zhang J, et al.
   (2024) Circulation Research

• Circular RNA Array
   [PMID: 39695693] Hu Y, et al.
   (2024) Molecular Cancer

• tRNA Sequencing
   [PMID: 38519786] Wu X, et al.
   (2024) Nature Cancer

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