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Microarray vs. Seq, How to Choose for Your tRNA Modification Study?

Arraystar offers both tRNA Modification Seq-m1A/m3C/m1G/m2,2G and Small RNA Modification Microarray for small RNA modification profiling. The comparison chart below can help you choose the most appropriate tool for your research purpose.


tRNA Modification Seq-m1A/m3C/m1G/m2,2G Small RNA Modification Microarray
For tRNA only For multiple small RNA classes including tRNAs, tsRNAs (tRFs and tiRNAs), miRNAs, and pre-miRNAs.
Single-base resolution of modification sites, important info for tRNA modifications at specific base positions in anticodon or body regions (Fig. 1). For modification detection regardless of modification sites in small size RNAs.
Simultaneous detection of multiple methylation types (m1A/m3C/m1G/m2,2G), for tRNAs that are typically modified by multiple types of modifications. One type of modification per project (Choose one from m6A/o8G/m7G/m5C/m1A/Ψ).
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Fig.1 Identify m1A, m3C, m1G, and m2,2G modifications by their induced misincorporation mutations in reverse transcription compared with demethylase-treated tRNA.



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Selected Publications

• Epitranscriptomic Array
   [PMID: 38355624] Xiong YW, et al.
   (2024) Nature Communications

• Small RNA Modification Array
   [PMID: 38747146] Zhang J, et al.
   (2024) Circulation Research

• Circular RNA Array
   [PMID: 39695693] Hu Y, et al.
   (2024) Molecular Cancer

• tRNA Sequencing
   [PMID: 38519786] Wu X, et al.
   (2024) Nature Cancer

New Services

rG4 Array Service
Uncover RNA G-quadruplexes functions
in biology and disease

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DoG RNA Array Service
Profile downstream-of-gene transcripts
& all their target types simultaneously

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tRNA Modification Seq Service
Profile m1A, m3C, m1G, m2,2G in tRNAs
at single-base resolution

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GlycoRNA Array Service
Cover Y-RNA/Y-RNA fragment, tRNA,
tiRNA&tRF, pre-miRNA, miRNA & more!

- What Are GlycoRNAs?
- Why Study GlycoRNAs?
- How to Study GlycoRNAs?

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Valid 09/01/2025 - 12/31/2025

 
 
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