What are DoG RNAs?

Downstream-of-Gene transcripts (DoG RNAs),a novel type of transcripts derived from protein-coding genes, are generated due to transcription termination failure and read-through transcription.

Why Study DoG RNAs?

DoG RNAs modulate gene transcription in diseases Learn more>>

  • DoG RNAs control the transcription of antisense overlapping genes in cell senescence
  • DoG RNAs affect genome 3D organization in viral infection

DoG-derived chimera RNAs and circular RNAs in cancers and diseases Learn more>>

DoG RNAs are subject to m6A, R-loop, or epigenetic regulation Learn more>>

How to Study DoG RNAs?

Arraystar Human Downstream-of-Gene Transcript (DoG RNA) Microarray is designed to profile and study human DoG RNAs. The array includes more than 13,000 probes to simultaneously detect and quantify DoG RNAs, pre-mRNAs of the host genes, and downstream overlapping transcripts as their potential regulatory targets at high accuracy and specificity (Fig. 1).

Fig 1. Arraystar DoG RNA Microarray probe design.

• Epitranscriptomic Array
   [PMID: 38355624] Xiong YW, et al.
   (2024) Nature Communications

• Small RNA Modification Array
   [PMID: 38747146] Zhang J, et al.
   (2024) Circulation Research

• Circular RNA Array
   [PMID: 39695693] Hu Y, et al.
   (2024) Molecular Cancer

• tRNA Sequencing
   [PMID: 38519786] Wu X, et al.
   (2024) Nature Cancer

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Valid 06/01/2025 - 08/31/2025