R-loops are RNA:DNA three-stranded hybrid structures formed between LncRNA/mRNA and the template DNA strand by base pairing. R-loops have important biological functions in DNA replication, epigenetic and transcription regulation.

Epigenetic regulation by R-loops

• DNA methylation regulation

• Chromatin remodeling

• lncRNA anchor

Transcription regulation by R-loops

• As gene promoter

• As regulator of transcription factor/repressor binding

• In transcription regulation stabilization

R-loops in human diseases

• Cancers

• Neurological disorders

• Autoimmune diseases

Learn more>>.

Fig. 1. R-loops in human diseases

Arraystar DRIPc-seq profiles LncRNA/mRNA organized R-loops in the genome. The DRIPc-seq, along with LncRNA Array, MeDIP-seq, or ChIP-seq, provides valuable functional insights in epigenetic and transcriptional regulation by R-loops.

Notes:
1. Offer valid through 5/31/2025. May not be combined with any other promotions or discounts.
2. Offer only valid for direct purchase from Arraystar Inc.
3. Minimum 6 samples (i.e. 3 samples in each condition/group) for R-loop differential analysis.

• Epitranscriptomic Array
   [PMID: 38355624] Xiong YW, et al.
   (2024) Nature Communications

• Small RNA Modification Array
   [PMID: 38747146] Zhang J, et al.
   (2024) Circulation Research

• Circular RNA Array
   [PMID: 39695693] Hu Y, et al.
   (2024) Molecular Cancer

• tRNA Sequencing
   [PMID: 38519786] Wu X, et al.
   (2024) Nature Cancer

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DRIPc-Sequencing Service
Promo: 20% OFF

- Profile mRNA/lncRNA organized R-loops
- Explore R-loop regulation in cancer
  and diseases
- Provide rich annotations and publication
  ready graphics
- Integrated analysis with LncRNA Array,
  MeDIP-seq , or ChIP-seq

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Valid through 5/31/2025