Fig. 1. circPHLPP2 facilitates colorectal cancer by its interaction with ILF3, enhancing IL36γ expression, and ultimately reducing NK cell cancer immunity and promoting cancer growth [1].

Customer Success Story

Arraystar CircRNA Microarray was used to profile circRNA expression in colorectal cancer [1]. circPHLPP2 is up-regulated in CRC resistant to anti-PD-1 cancer therapy. circPHLPP2 significantly promotes CRC proliferation and growth, whereas circPhlpp2 knockdown enhances anti-PD-1 efficacy. Mechanistically, circPHLPP2 interacts with ILF3 to enhance IL36γ transcription, which reduces NK cell infiltration, granzyme B and IFN-γ production, thereby promoting cancer immune evasion and progression.

Arraystar CircRNA Arrays

• Circular junction-specific probes, linear RNA removal and efficient circRNA labeling ensure the most specific, accurate, and reliable circRNA expression profiling.

• Detailed annotation specific to circRNA biology to unravel functional roles as miRNA sponges.

• The preferred choice over RNA-sequencing, due to the particular properties of circular RNA.

Reference
[1] Hu Y. et al (2024) "Circular RNA circPHLPP2 promotes tumor growth and anti-PD-1 resistance through binding ILF3 to regulate IL36 transcription in colorectal cancer." Mol Cancer 23(1):272 [PMID:39695693]

• Epitranscriptomic Array
   [PMID: 38355624] Xiong YW, et al.
   (2024) Nature Communications

• Small RNA Modification Array
   [PMID: 38747146] Zhang J, et al.
   (2024) Circulation Research

• Circular RNA Array
   [PMID: 39695693] Hu Y, et al.
   (2024) Molecular Cancer

• tRNA Sequencing
   [PMID: 38519786] Wu X, et al.
   (2024) Nature Cancer

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