What Are GlycoRNAs?

GlycoRNAs are glycosylated small non-coding RNAs, including Y-RNAs, tRNAs, miRNAs, snRNAs, rRNAs, and snoRNAs.

GlycoRNAs in Diseases.

GlycoRNAs have emerged as a new area of study in cancer, cardiovascular, neurological, immune, and respiratory diseases, opening up new avenues into novel biomarker and therapeutic applications.

Fig 1. Heatmap of glycoRNA levels on breast cancer cells at different malignancy and metastasis stages as measured by sialic acid aptamer and RNA in situ hybridization-mediated proximity ligation assay (ARPLA).

How to study GlycoRNAs?

Arraystar GlycoRNA Array combines biochemical methods for glycoRNA capture/detection with Arraystar microarray to quantify and profile glycoRNA expression. The integration of these advanced techniques leverages their technical strengths to achieve high specificity, sensitivity, and accuracy.

The array covers a wide range of glycosylated small RNA classes, including Y-RNAs/Y-RNA fragments, tRNAs, tsRNAs (tiRNAs & tRFs), pre-miRNAs, miRNAs, snRNAs/snRNA fragments, scRNAs, rRNAs/rRNA fragments, and snoRNAs/snoRNA fragments.

Using this cutting-edge approach, researchers can gain comprehensive glycoRNA expression details to discover and understand this new class of RNA molecules in gene regulation, cellular functions and human diseases.

• Epitranscriptomic Array
   [PMID: 38355624] Xiong YW, et al.
   (2024) Nature Communications

• Small RNA Modification Array
   [PMID: 38747146] Zhang J, et al.
   (2024) Circulation Research

• Circular RNA Array
   [PMID: 39695693] Hu Y, et al.
   (2024) Molecular Cancer

• tRNA Sequencing
   [PMID: 38519786] Wu X, et al.
   (2024) Nature Cancer

GlycoRNA Array Service

Cover Y-RNA/Y-RNA fragment, tRNA,
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DRIPc-Sequencing Service
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- Profile mRNA/lncRNA organized R-loops
- Explore R-loop regulation in cancer
  and diseases
- Provide rich annotations and publication
  ready graphics
- Integrated analysis with LncRNA Array,
  MeDIP-seq , or ChIP-seq

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Valid through 5/31/2025