Fig. 1. Graphic abstract of m7A RNA modification in cardiac hypertrophy and disease [1].

Customer Success Story

Heart diseases are a leading cause of deaths. This study elucidates the role of Mettl1 methyltransferase and m7G RNA modification in cardiac hypertrophy and heart failure [1]. m7G was found to target SRSF9/NFATc4 axis that regulates cardiac hypertrophy. During stress, transcription factor YY1 upregulates Mettl1 to modify SRSF9 mRNA with m7G, which in turn promotes intron retention splicing and stabilization of NFATc4, leading to cardiac hypertrophic growth. Arraystar Epitranscriptomic Microarray was used in this study.

Reference

[1] Yu S. et al (2024) The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4. Adv Sci (Weinh) [PMID:38810124]

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Array Epitranscriptomic Arrays

m6A/m5C/m1A/ac4C/m7G/Ψ

Over 20% OFF Valid through 3/31/2025

• A single microarray to simultaneously profile what gene transcripts are modified, differential modification between conditions, and very importantly, the percentage of modification for each transcript.

• Excellent coverage for coding and noncoding RNA classes, even for lncRNAs and circRNAs that are difficult to profile by MeRIP-seq.

• rRNA depletion not required. Faster, simpler than MeRIP-seq.

• Low sample amount required, starting from as little as 1 ug total RNA for mRNAs & LncRNAs or 3 ug for circRNAs.

• Epitranscriptomic Array
   [PMID: 38355624] Xiong YW, et al.
   (2024) Nature Communications

• Small RNA Modification Array
   [PMID: 38747146] Zhang J, et al.
   (2024) Circulation Research

• Circular RNA Array
   [PMID: 39695693] Hu Y, et al.
   (2024) Molecular Cancer

• tRNA Sequencing
   [PMID: 38519786] Wu X, et al.
   (2024) Nature Cancer

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