Fig 1.Graphical abstract [1].

Customer Success Story

Threonine is a substrate for t6A modification of tRNAs by YRDC enzyme. When accumulated in glioblastoma cells due to altered cancer metabolism, t6A modified tRNAs increase global translation and shift the translated proteome by their changed codon bias toward mitosis-related genes [1].

Arraystar tRNA-seq was used to analyze tRNA isoform abundances under the condition. The study elucidates the mechanism of translational and metabolic reprogramming in cancer. It provides a molecular basis for dietary threonine restriction to reduce tumor t6A formation, inhibit tumor growth, and augment cancer chemotherapy efficacy.

Reference

[1] Wu X. et al (2024) Threonine fuels glioblastoma through YRDC-mediated codon-biased translational reprogramming. Nat Cancer [PMID:38519786]

Arraystar tRNA Sequencing Service

• Efficiently remove modifications in the tRNAs to reach unprecedented level of tRNA-seq efficiency and accuracy

• Performance optimized methodologies with rigorous QC process

• Comprehensive tRNA reference from all authoritative databases

• Thorough tRNA annotation, bioinformatic analysis, and data visualization with publication quality graphics

• Work well together with our broad portfolio of tRNA research technologies: tRF&tiRNA-seq, tRF&tiRNA PCR array, tRNA PCR array and tRNA modification analysis.

• Epitranscriptomic Array
   [PMID: 38355624] Xiong YW, et al.
   (2024) Nature Communications

• tRNA Sequencing
   [PMID: 38519786] Wu X, et al.
   (2024) Nature Cancer

• Circular RNA Array
   [PMID: 37004067] Zhong GL, et al.
   (2023) Molecular Cancer

• m6A Single Nucleotide Array
   [PMID: 36631441] Yan W, et al.
   (2023) International Journal of Oral
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