In addition to m6A as the most studied prominent internal epitranscriptomic modification in mRNAs and lncRNAs, other epitranscriptomic modifications, such as m1A, m5C, ac4C, m7G, and Ψ, have been increasingly discovered to play novel biological or clinical roles. These RNA modifications can modulate mRNA translation, alternative splicing, nuclear export and stability; affect RNA secondary structures and protein-RNA interactions; and regulate DNA repair. They are also involved in diverse cancers, viral infections, and pathogen infection-induced myelopoiesis.

Arraystar mRNA&lncRNA and circRNA Epitranscriptomic Microarray Services expand the service offerings from m6A to other vital modifications, such as m5C/m1A/ac4C/m7G/Ψ, to broaden your research in epitranscriptomics.

Benefits

• A single Epitranscriptomic Microarray to simultaneously profile what gene transcripts are modified, differential modification between conditions, and very importantly, the percentage of modification for each transcript (Fig1).

• Excellent coverage for coding and noncoding RNA classes, even for lncRNAs and circRNAs that are difficult to profile by MeRIP-seq.

• Low sample amount required, starting from as little as 3 µg total RNA.

Fig 1.The changing modification stoichiometry generates functional diversity from the same RNA transcript.

P.S. We also offer epitranscriptomic sequencing service for m6A/ m5C/m1A/ac4C/m7G/Ψ modifications. To Learn More>>

• Circular RNA Array
   [PMID: 37004067] Zhong GL, et al.
   (2023) Molecular Cancer

• m6A Single Nucleotide Array
   [PMID: 36631441] Yan W, et al.
   (2023) International Journal of Oral
   Science

• tRNA PCR Array
   [PMID: 37283053] Wang C, et al.
   (2023) Nucleic Acids Research

• LC-MS Based tRNA Modification
   [PMID: 37563288] Li G, et al.
   (2023) Nature Microbiology

DRIPc-Seq
provides valuable functional insights in transcriptional regulation by LncRNA/mRNA organized R-loops.

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