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Customer Success Story
circPTEN circular RNA was discovered down regulated in clear cell renal cell carcinoma (ccRCC) on Arraystar circRNA Microarray [1]. circPTEN regulates DNMT1 which epigenetically controls tumor suppressor PTEN gene expression (Fig. 1, left), and METTL3 which epitranscriptomically modifies glucose transporter GLUT1 mRNA (Fig. 2, right). Both mechanisms suppress the kidney cancer and mTOR inhibitor cancer drug resistance via mTOR pathway.
Reference
[1] Zhan Y, et al (2023) CircPTEN suppresses human clear cell renal carcinoma progression and resistance to mTOR inhibitors by targeting epigenetic modification.
Drug Resistance Updates
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Arraystar CircRNA Arrays
• The effective and practical platform for highly sensitive and specific circular RNA profiling.
• Circular junction-specific probes, linear RNA removal and efficient circRNA labeling ensure the most specific, accurate and reliable circRNA expression profiling
• Detailed annotation specific to circRNA biology, e.g. miRNA binding sites, miRSVR scores and conservation status, to unravel functional roles as miRNA sponges.
• The preferred choice over RNA-sequencing, due to the particular properties of circular RNAs >>
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