Arraystar circRNA Arrays
• The effective and practical platform for highly sensitive and specific circular RNA profiling.
• Circular junction-specific probes, linear RNA removal and efficient circRNA labeling ensure the most specific, accurate and reliable circRNA expression profiling
• Detailed annotation specific to circRNA biology, e.g. miRNA binding sites, miRSVR scores and conservation status, to unravel functional roles as miRNA sponges.
• The preferred choice over RNA-sequencing, due to the particular properties of circular RNAs.
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Customer Success Story
Rescuing ischemic penumbra tissue is the main goal of acute ischemic stroke (AIS) clinical treatment. By Arraystar circRNA Microarray profiling, CircOGDH (circular RNA derived from oxoglutarate dehydrogenase) was discovered dramatically and selectively upregulated in the penumbra of mouse AIS model and validated in the plasma of AIS patients [1]. Further, sequestering of miR-5112 by CircOGDH enhances the COL4A4 expression to elevate neuron damage. CircOGDH knockdown significantly enhances neuronal cell viability under ischemic conditions. Thus, CircOGDH can be a potential therapeutic target and developed as a simple, fast, inexpensive, and noninvasive biomarker for AIS clinical management.
Reference
[1] Liu Y. et al (2022) CircOGDH Is a Penumbra Biomarker and Therapeutic Target in Acute Ischemic Stroke.Circ Res 130(6):907-924 [PMID:35189704]
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Circular RNA Profiling
Accurate CircRNA Profiling with Rich Analysis
Cited by+600 Publications
Valid 06/01/2023 - 08/31/2023
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