Arraystar CircRNA Arrays

• The effective and practical platform for highly sensitive and specific circular RNA profiling.

• Circular junction-specific probes, linear RNA removal and efficient circRNA labeling ensure the most specific, accurate and reliable circRNA expression profiling
• Detailed annotation specific to circRNA biology, e.g. miRNA binding sites, miRSVR scores and conservation status, to unravel functional roles as miRNA sponges.
• The preferred choice over RNA-sequencing, due to the particular properties of circular RNAs.

15% OFF Circular RNA Profiling

Accurate CircRNA Profiling with Rich Analysis
Cited by +600 Publications

Valid 06/01/2023 - 08/31/2023

Customer Success Story

By profiling circRNA expression using Arraystar circRNA Microarray, diabetes-induced circulation associated circular RNA (DICAR) was found down regulated in diabetic mouse hearts [1]. DICAR is a regulator of cardiac dysfunction, cardiac cell hypertrophy, and cardiac fibrosis as established by KO and transgenic models. DICAR efficiently inhibits diabetic cardiomyocyte pyroptosis via valosin containing protein (VCP) blocking of Med12 protein degradation. Synthetic DICAR containing only the circular junction part (DICAR-JP) could rescue the cardiac impairments.

Reference

[1] Yuan Q. et al (2023) CircRNA DICAR as a novel endogenous regulator for diabetic cardiomyopathy and diabetic pyroptosis of cardiomyocytes. Signal Transduct Target Ther 8(1):99 [PMID:36882410]

Circular RNA
• Yuan Q, et al. (2023)
   Signal Transduction &Targeted Therapy
   [PMID: 36882410]
• Zhong GL, et al. (2023)
   Molecular Cancer
   [PMID: 37004067]

RNA Modification
• Yan W, et al. (2023)
   International Journal of Oral Science
   [PMID: 36631441]

DRIPc-Seq provides valuable functional insights in transcriptional regulation by LncRNA/mRNA organized R-loops.

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15% OFF CircRNA Array
Accurate CircRNA Profiling with Rich Analysis
Valid Through 08/31/2023
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