Fig. 1. Bubble plot of GSEA analysis of the 9-lncRNA signature with immunological pathways in locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients.

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Nine lncRNAs are identified as a nasopharyngeal carcinoma cancer signature through Arraystar lncRNA microarray profiling followed by machine learning training [1]. The lncRNA signature classifies patients into low and high risk groups for metastasis and survival. The lncRNAs are correlated with immune activity and lymphocyte infiltration by integrative analyses. Importantly, the lncRNA cancer signature outperforms traditional anatomy-based metrics in identifying patients with high metastatic risk.

Reference

[1] Liang YL. et al (2022) A lncRNA signature associated with tumor immune heterogeneity predicts distant metastasis in locoregionally advanced nasopharyngeal carcinoma. Nat Commun 13(1):2996 [PMID:35637194]

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