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Customer Success Story
Using Arraystar circRNA Microarray, the circRNA expression was profiled with TGF-β agonist treatment in cancer cells. CDR1as was found to be the top differentially expressed circRNA [1].
Further, CDR1as facilitates IGF2BP1 to stabilize m6A modified Slug mRNA, a key EMT factor. Additionally, CDR1as activates other TGF-β signaling factors known to promote EMT, including P-Smad2 and P-Smad3. Thus, CDR1as promotes cervical cancer metastasis and shortens cancer survival.
Reference
[1] Zhong G. et al (2023) TGF-β signaling promotes cervical cancer metastasis via CDR1as.
Mol Cancer 22(1):66 [PMID:37004067]
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Arraystar CircRNA Arrays
• The effective and practical platform for highly sensitive and specific circular RNA profiling.
• Circular junction-specific probes, linear RNA removal and efficient circRNA labeling ensure the most specific, accurate and reliable circRNA expression profiling.
• Detailed annotation specific to circRNA biology, e.g. miRNA binding sites, miRSVR scores and conservation status, to unravel functional roles as miRNA sponges.
• The preferred choice over RNA-sequencing, due to the particular properties of circular RNAs.
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