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Programmed death ligand-1 (PD-L1) is a factor for cancer cells to evade host immune surveillance. Recently published in Mol. Cancer (2022), PD-L1 was discovered a target of m6A writer METTL3 by Epitranscriptomic Array in METTL3 knockdown cells [1]. m6A modified PD-L1 mRNA is stabilized by IGF2BP3 reader. Down-regulation of PD-L1 mRNA m6A modification enhances anti-tumor immunity via T cell activation, exhaustion, and infiltration.

Benefits of Epitranscriptomics Arrays

Arraystar Epitranscriptomic Microarrays have unique advantages over MeRIP-seq.

      •  A single Epitranscriptomic Microarray to simultaneously profile what gene transcripts are modified, differential modification, and the modification stoichiometry for each transcript.
         
      •   Excellent coverage for coding and noncoding RNA classes, even for lncRNAs and circRNAs that are difficult to profile by MeRIP-seq.
         
      •   Low sample amount required, starting from as little as 3 ug total RNA.

Circular RNA
• Yuan Q, et al. (2023)
   Signal Transduction &Targeted Therapy
   [PMID: 36882410]
• Zhong GL, et al. (2023)
   Molecular Cancer
   [PMID: 37004067]

RNA Modification
• Yan W, et al. (2023)
   International Journal of Oral Science
   [PMID: 36631441]

DRIPc-Seq provides valuable functional insights in transcriptional regulation by LncRNA/mRNA organized R-loops.

eccDNA Seq not only dramatically increases eccDNA reads, but also simultaneously profiles both of micro-eccDNA and mega-eccDNA, accelerating your biomarker discovery and cancer research.

The Latest Highlights on
CircRNA in Cancer
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15% OFF Epitranscriptomic Array
Only 5ug total RNA is required
Cover mRNA & LncRNA, or circRNA modifications
Valid 02/01/2023 - 5/31/2023
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