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Customer Success Story
m6A epitranscriptomic modification plays important roles in circular RNA biology. By circRNA epitranscriptomic microarray profiling [1], circORC5 was found differentially m6A modified by METTL14 writer in gastric cancer. m6A modification down-regulates circORC5 that can sponge and
sequester miR-30c-2-3p in the cytoplasm. The upregulated miR-30c-2-3p down-regulates oncogenic AKT1S1 and EIF4AB, thereby suppressing the gastric cancer progression.
Reference
[1] Fan HN. et al (2022) METTL14-mediated m(6)A modification of circORC5 suppresses gastric cancer progression by regulating miR-30c-2-3p/AKT1S1 axis.
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Arraystar CircRNA Epitranscriptomic Arrays
• The easiest method to profile m6A modification of circRNAs. Unique advantages to overcome many difficulties by MeRIP-seq.
• One Epitranscriptomic Microarray to simultaneously profile what circRNAs are modified, differential modification between conditions, and importantly, the percentage of modification for each circRNA
• Low required sample amounts, starting from as little as 3 ug total RNA
Current Promotion
15% OFF Epitranscriptomic Profiling
-Cover mRNA & LncRNA, or circRNA Modifications
Valid 02/01/2023 - 05/31/2023
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