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Customer Success Story
On Arraystar Super-enhancer LncRNA microarray, a super-enhancer was found activated by TGF-/SMAD3 pathway to produce super-enhancer lncRNA LINC01977 [1]. LINC01977 tethers the SMAD2/3/4 complex in the nucleus and transcriptionally promotes the expression of ZEB1, the central switch of the epithelial–mesenchymal transition (EMT) that lead to lung adenocarcinoma progression and metastasis. These results highlight the potential of super-enhancer hijacked lncRNAs as prognostic biomarkers and therapeutic targets for lung cancer.
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Arraystar Super-enhancer LncRNA Arrays
• Comprehensive collection of SE-lncRNAs and super-lncRNAs
• Simultaneous profiling of the target mRNA genes associated with SE-lncRNAs
• Entire sets of transcription factors and oncogenes
• Detailed annotations for SE-lncRNA, super-enhancer, and their targets
• Unambiguous and reliable SE-lncRNA isoform detection
• Efficient target labeling for sensitive detection of labile SE- lncRNAs
• Superior quantification of LncRNAs over RNA-seq
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