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Customer Success Story
By circRNA microarray profiling [1], circGPR137B was found down-regulated in hepatocellular carcinoma (HCC). miR-4739 is AGO2 complexed functional target of the circGPR137B sponge activity. Further, m6A demethylase FTO mRNA is target of miR-4739. Demethylated circGPR137 has increased expression. Thus, circGPR137B/miR-4739/FTO form a feedback, which can suppress liver and lung cancers.
Reference
[1] Liu L. et al (2022) CircGPR137B/miR-4739/FTO feedback loop suppresses tumorigenesis and metastasis of hepatocellular carcinoma. Mol Cancer 21(1):149 [PMID:35858900]
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Arraystar CircRNA Microarrays
• The only practical platform for highly sensitive and specific circular RNA profiling.
• Circular junction-specific probes, linear RNA removal, and efficient circRNA labeling ensure the most specific, accurate, and reliable circRNA expression profiling.
• Detailed annotation specific to circRNA biology, e.g. miRNA binding sites, miRSVR scores and conservation status, to unravel functional roles as miRNA sponges.
• The preferred choice over RNA-sequencing, due to the particular properties of circular RNA.
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