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Customer Success Story
Using Arraystar Human circRNA microarray, the circular RNA expression in peripheral blood specimens from CRC patients was profiled. circALG1 was found highly expressed in both peripheral blood and tumour tissues and associated with CRC metastasis. Furthermore, circALG1 up-regulates placental growth factor (PGF) via binding to miR-342-5p, which is enhanced by m6A modification. circALG1 has the potentials as a CRC prognostic marker and a therapeutic target.
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Arraystar CircRNA Arrays
• The only practical platform for highly sensitive and specific circular RNA profiling.
• Circular junction-specific probes, linear RNA removal, and efficient circRNA labeling ensure the most specific, accurate and reliable circRNA expression profiling.
• Detailed annotation specific to circRNA biology, e.g. miRNA binding, to unravel functional roles as miRNA sponges.
• The preferred choice over RNA-sequencing, due to the particular molecular properties of circular RNA.
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