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Customer Success Story
Using Arraystar tRNA-seq, tRNA-Leu(TAA) was found down-regulated in velcrin anticancer drug treated cancer cells. Velcrin
promotes the cleavage of tRNA-Leu(TAA) by inducing PDE3A–
SLFN12 complex formation with specific RNase activity. The ensuing ribosome pausing at Leu-TTA codons and global inhibition of protein synthesis define a new mechanism of cancer cell apoptosis by the drug treatment.
Reference
[1] Lee S. et al (2022) Velcrin-induced selective cleavage of tRNA(Leu)(TAA) by SLFN12 causes cancer cell death. Nat Chem Biol : [PMID:36302897]
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Arraystar tRNA-seq
• Efficiently removal of tRNA modifications to reach unprecedented level of efficiency and accuracy
• Performance optimized tRNA sequencing methodologies with rigorous QC process
• Comprehensive tRNA transcriptome reference from all authoritative databases
• Thorough tRNA annotation and bioinformatic analysis
• Work seamlessly together with our tRNA technologies: tRF&tiRNA-seq, tRF&tiRNA PCR array, tRNA Repertoire PCR arrayand tRNA modification analysis
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