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    New Launch - DRIP-Seq Service for Studying R-loop Regulation!


R-loops are RNA:DNA three-stranded hybrid structures formed between nascently transcribed RNA strand and the template DNA strand by base pairing. Often located in the CpG islands of the promoters or transcription stop sites, R-loops have important biological functions in DNA replication, epigenetic and transcription regulation. Learn more>>.

Arraystar DRIP-seq (DNA:RNA hybrid immunoprecipitation and sequencing) profiles R-loops in the genome. The DRIP-seq, along with LncRNA Array, MeDIP-seq, or ChIP-seq, provides valuable functional insights in epigenetic and transcriptional regulation by R-loops.

Epigenetic regulation by R-loops
• DNA methylation regulation
• Chromatin remodeling
• R-loop as an lncRNA anchor

Transcription regulation by R-loops
• R-loop as a gene promoter
• R-loop as a regulator of transcription factor/repressor binding
• R-loop stabilization in transcription regulation

Recent evidence suggests that R-loops are involved in a number of human diseases including neurological disorders, cancer, and autoimmune diseases (Fig 1). 		 

Fig. 1. R-loops in human diseases


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Latest Publications

tRNA/tsRNA
• Wang J, et al. (2022) Nature
    [PMID: 35322228]

RNA Modification
• Wan W, et al. (2022) Molecular Cancer
    [PMID: 35197058]
• Fan H N, et al. (2022) Molecular Cancer
    [PMID: 35164771]
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Raising the Bar of Multi-transcriptomic Profiling of Small RNAs
• Small RNA biotypes and functional mechanisms
• Biomarker uses of small RNAs
• Challenges of quantifying small RNAs
• Arraystar small RNA profiling technologies
• Roadmap to study small RNA expression

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15% OFF LncRNA Array
Valid 07/01/2022 - 10/31/2022

Best for LncRNAs Often at Low Abundance
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