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Breast Cancer
The circACTN4 interacts with FUBP1 to promote tumorigenesis and progression of breast cancer by regulating the expression of proto-oncogene MYC. Wang X, et al. Molecular Cancer, 2021
An antisense circular RNA circSCRIB enhances cancer progression by suppressing parental gene splicing and translation. Ma J, et al. Molecular Therapy, 2021
Liver Cancer
CircMEMO1 modulates the promoter methylation and expression of TCF21 to regulate hepatocellular carcinoma progression and sorafenib treatment sensitivity. Dong Z R, et al. Molecular Cancer, 2021
Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling. Gu Y, et al. Molecular Cancer, 2021
Circular RNA ACTN4 promotes intrahepatic cholangiocarcinoma progression by recruiting YBX1 to initiate FZD7 transcription. Chen Q, et al. Journal of Hepatolog, 2021
Leukemia
CircRNF220, not its linear cognate gene RNF220, regulates cell growth and is associated with relapse in pediatric acute myeloid leukemia. Liu X, et al. Molecular Cancer, 2021
Cervical Carcinoma
AUF1 ligand circPCNX reduces cell proliferation by competing with p21 mRNA to increase p21 production. Tsitsipatis D, et al. Nucleic Acids Research, 2021
Intestinal Mucosal Injury
Circular RNA circHIPK3 promotes homeostasis of the intestinal epithelium by reducing miR-29b function. Xiao L, et al. Gastroenterology, 2021
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